[Comparison between efficacy of Tamsulosin and Terazosinin alpha-adrenergic blockers in spontaneous passage of ureter stones after ESWL [A double blind clinical trial]]

Nephrolithiasis has a high prevalence in population. Our objective was to compare time of stone passage, severity of pain, frequency of the use of analgesics and the course of disability between groups A, B and C. In this randomized controlled trial study, 240 patients were selected .inclusion criteria was all patient with 5-9mm stone diameter, and exclusion criteria was opium addiction. All of patients were categorized in 3 groups with Block Balance Randomize and double blind method. Each group consisted of 80 persons. In group A [i.e. control group] patients were given daily Diclofenac suppositories of 100mg and Diclofenac tablets of 25mg.In group B patients were given Tamsulosin tablets of 0.4 mg in addition to routine treatment and in group C patients were given Terazosin tablets of 2 mg in addition to routine treatment. Patients were visited three months after lithotripsy. The rate of ureteral stone passage in group B [85.5%] was more than group A [80%] and group C [83.3%], the mean expulsion time group A with 14.9 days was more than group B [12.1 days] and group C [12.2 days],also severity of pain on the basis of VAS chart in group B [4.7] less than group A [5.5] and C [5.2], extra analgesic requirement in alpha blockers group [B:4 patients and C:2 patients] less than control group [8 patients], and all of these were non significantly different. alpha blockers are decrease symptoms of pain and no effective response on expulsion of stones

[Comparison of therapeutic effects intranasal Desmopressin, Pethidine and their combination in renal colic]

Standard treatment in renal colic is established with narcotics. NSAIDS are alternative choices. Several studies are done on various treatments. This study was done to evaluate the effect of intranasal Desmopressin alone and in combination with parenteral Pethidine in relief of renal colic pain. In this clinical trial study, 150 patients with renal colic were recruited in: Group one received 40 micrograms intranasal desmopressin, group two 25 miligrams intravenous pethidine and in group 3 both drugs were administered. VAS method was used to measure the intensity of pain in first minute and at 10, 20 and 30 minutes after administration. Kruskal-Walis and ANOVA were used to compare the pain severity between groups. Pain intensity had significant decrease after 10, 20 and 30 minutes; in all groups [P < 0.05]. Group 3 showed maximum decrease after 30 minutes. This study determined that combined administration of desmopressin and pethidine can significantly decrease in renal colic intensity. We suggest the use of desmopressin, in combination with other medicines; as a supportive and effective treatment in renal colic patients